For research use only
| Product Infomation | |
| Product Name | GB-88 |
|---|---|
| CAS No. | 1416435-96-5 |
| Molecular Weight | 546.70 |
| Formula | C₃₂H₄₂N₄O₄ |
| SMILES | O=C([C@H]([C@@H](C)CC)NC([C@H](CC1CCCCC1)NC(C2=CC=NO2)=O)=O)N3CCC4(C=CC5=C4C=CC=C5)CC3 |
| Stock status | Instock |
Online consultation: 
Product description:
| Description | GB-88 is an oral, selective non-peptide antagonist of PAR2, inhibits PAR2 activated Ca2+ release with an IC50 of 2 µM[1].
| |
| IC50 & Target | PAR2[1] | |
| In Vitro | GB-88 (10 mg/kg, p.o. in olive oil) is both orally active and
anti-inflammatory in vivo, with specific antagonist activity against
four structurally and mechanistically different PAR2 agonists
(2f-LIGRLO-NH2, trypsin, SLIGRL-NH2 and GB110)[1]. | |
| Powder | -20°C | 3 years |
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month | |
Peferences:
[1]. Suen JY, et al. Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110). Br J Pharmacol. 2012 Mar;165(5):1413-23.
