For research use only
| Product Infomation | |
| Product Name | GGTI-2418 |
|---|---|
| CAS No. | 501010-06-6 |
| Molecular Weight | 441.52
|
| Formula | C₂₃H₃₁N₅O₄ |
| SMILES | CC(C)C[C@@H](C(O)=O)NC(N1[C@@H](CC2=CC=CC=C2)C(N(CC3=C(C)N=CN3)CC1)=O)=O |
| Stock status | Instock |
Online consultation: 
Product description:
| Description | GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors[1]. | |
| IC50 & Target | IC50: 9.5 nM (GGTase I), 53 μM (FTase)[1] | |
| In Vitro | GGTI-2418 inhibits GGTase I and FTase activities with IC50s
of 9.5±2.0 nM and 53±11 μM, respectively, a 5,600-fold selectivity
toward inhibition of GGTase I versus FTase. GGTI-2418 demonstrates
competitive inhibition of GGTase I against the H-Ras-CVLL protein with a
Ki of 4.4±1.6 nM[1]. GGTi-2418 (10-15 μM; 16 hours) treatment delocalizes FBXL2 and stabilizes IP3R3[2]. | |
| Powder | -20°C | 3 years |
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month | |
Peferences:
[1]. Kazi A, et al. Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy. Mol Cell Biol. 2009 Apr;29(8):2254-63.
