For research use only
| Product Infomation | |
| Product Name | RMC-4550 |
|---|---|
| CAS No. | 2172651-73-7 |
| Molecular Weight | 355.27 |
| Formula | C₂₁H₂₆Cl₂N₄O₂ |
| SMILES | ClC1=C(C(C2=NC(CO)=C(N=C2C)N3CCC4(CC3)CO[C@H]([C@H]4N)C)=CC=C1)Cl |
| Stock status | Instock |
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Product description:
| Description | RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM. | |
| IC50 & Target | IC50:0.583 nM (SHP2)[1]. | |
| In Vitro | RMC-4550 is an allosteric inhibitor of SHP2 and stabilizes the auto-inhibited conformation of wild-type SHP2 enzyme, with a mode of inhibition similar to SHP099. Consistent with an allosteric mode of inhibition, RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide, but lacks activity against the free catalytic domain of SHP2[1]. | |
| Powder | -20°C | 3 years |
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month | |
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