For research use only
| Product Infomation | |
| Product Name | ZT-12-037-01 |
|---|---|
| CAS No. | 2328073-61-4 |
| Molecular Weight | 385.50 |
| Formula | C₂₁H₃₁N₅O₂ |
| SMILES | COC1=CC2=NC(NC3CC3)=NC(NC4CCN(C(C)C)CC4)=C2C=C1OC |
| Stock status | Get quote |
Online consultation: 
Product description
| Description | ZT-12-037-01 is a STK19-targeted inhibitor, has a high-affinity interaction with STK19 protein and inhibits oncogenic NRAS-driven melanocyte malignant transformation. ZT-12-037-01 is an ATP-competitive inhibitor, inhibiting phosphorylation of NRAS (major isoform of Ras family) with an IC50 of 24 nM[1]. | |
| IC50 & Target | ________________________________________________________________________________________ | |
| In Vitro | _________________________________________________________________________________________ ZT-12-037-01 (0-3 μM) has an inhibitory effects of ZT-12-037-01 on STK19WT and STK19D89N-activated NRAS phosphorylation in HPMs[1]. | |
| Powder | -20°C | 3 years |
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month | |
Peferences:
[1]. Yin C, et al. Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Cell. 2019 Feb 21;176(5):1113-1127.e16.
