For research use only
| Product Infomation | |
| Product Name | HS-10296 |
|---|---|
| CAS No. | 1899921-05-1 |
| Molecular Weight | 525.64 |
| Formula | C₃₀H₃₅N₇O₂ |
| SMILES | COC(C=C(N(C)CCN(C)C)C(NC(C=C)=O)=C1)=C1NC2=NC(C3=CN(C4CC4)C5=C3C=CC=C5)=CC=N2 |
| Stock status | Get quote |
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Product description
| Description | HS-10296, an orally available and third-generation EGFR-activating mutations and T790M-resistant mutation inhibitor, shows limited activity against wild-type EGFR[1][2]. | |
| IC50 & Target | ________________________________________________________________________________________ EGFRT790M | |
| In Vitro | _________________________________________________________________________________________ HS-10296 is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC[1]. Additionaly, HS-10296 could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q[2]. | |
| Powder | -20°C | 3 years |
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month | |
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