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Product Infomation
Product NameCC-90003
CAS No.1621999-82-3
Molecular Weight

458.44

Formula

C₂₂H₂₁F₃N₆O₂

SMILES

C=CC(NC1=CC(C)=CC=C1NC2=NC(NC3=CC(OC)=NC=C3C)=NC=C2C(F)(F)F)=O

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Product description

Description

CC-90003 is an irreversible and selective inhibitor of ERK 1/2 with antitumor activity.


IC50 & Target

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ERK2


In Vitro

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Powder-20°C3 years

4°C2 years
In solvent-80°C6 months

-20°C1 month







Peferences:

 [1]. Monica M. Mita, et al. A phase Ia study of CC-90003, a selective extracellular signal-regulated kinase (ERK) inhibitor, in patients with relapsed or refractory BRAF or RAS-mutant tumors. Journal of Clinical Oncology 35, no. 15_suppl (May 20 2017) 2577-2577.